Résumés de recherche sur la COVID-19 par Essential Evidence Plus (EE+)

Résumés de recherche sur la COVID-19 par Essential Evidence Plus (EE+)

Alors que la pandémie de COVID-19 continue d’évoluer, l’équipe de Joule travaille en étroite collaboration avec le Dr Mark Ebell, rédacteur en chef d’EE+ et avec l’équipe de la maison d’édition Wiley pour transmettre aux médecins les résumés de recherche les plus récents.

Les personnes abonnées à POEMs* recevront des résumés de recherche liés à la COVID-19 la plupart des fins de semaine et certains jours en semaine. Vous pouvez voir ces mises à jour ci-dessous, vous abonner pour recevoir des résumés de recherche POEMs quotidiens, consulter les archives de POEMs (connexion au compte amc.ca requise) pour commenter ces résumés ou obtenir des crédits de DPC, ou consulter la page Web d’Essential Evidence Plus consacrée à la COVID-19.

Essential Evidence Plus (EE+) offre un accès gratuit à des renseignements pertinents sur la COVID-19 pour aider les médecins à soigner les patients du monde entier. Les sujets liés aux Infections au Coronavirus SRAS-CoV-2 (COVID-19) sont mis à jour lorsqu’il y a de nouveaux développements.

Question clinique

Can physical distancing reduce the transmission of COVID-19? Is colchicine a potential treatment option?

L’Essentiel

Physical distancing measures are effective in reducing COVID-19 transmission. Colchicine yielded small clinical improvements in a preliminary randomized trial. 2c

Auteur(s)

John Hickner, MD, MS

Question clinique

What longer term symptoms follow hospitalization for COVID-19? Is a vaccine developed in China a possible solution?

L’Essentiel

Persistent fatigue, dyspnea, and other symptoms commonly follow hospitalization for COVID-19. Chinese researchers report a successful Phase 2 trial of a COVID-19 vaccine. 2c

Auteur(s)

Mark H. Ebell, MD, MS

Question clinique

What is the progress on the development of a vaccine against SARS-CoV-2?

L’Essentiel

There is promising early data from the United States and the United Kingdom on new vaccines to prevent COVID-19. 3b

Auteur(s)

Henry C. Barry, MD, MS

Question clinique

How effective is antibody testing for diagnosing COVID-19? What can a population-based study that tested 86% of the population in an Italian town tell us about infection rates?

L’Essentiel

The accuracy of antibody tests for COVID-19 are highly variable. The results from a study that tested an entire town in Italy during the peak of the epidemic suggest an infectious period between 3.6 days to 6.5 days, with infectiousness peaking on the day of symptom onset. 2c

Auteur(s)

Mark H. Ebell, MD, MS

Question clinique

Can personal protective equipment protect healthcare workers who are exposed to SARS-CoV-2 from developing COVID-19?

L’Essentiel

Healthcare workers in Wuhan who were wearing personal protective equipment (PPE) when exposed to SARS-CoV-2 did not become infected. 2c

Auteur(s)

Henry C. Barry, MD, MS

Question clinique

How should diabetes be managed in patients who choose to fast during Ramadan?

L’Essentiel

These expert-derived guidelines are updated from <a href="https://www.essentialevidenceplus.com/content/poem/71256">earlier recommendations</a> for managing diabetes in Muslim patients who desire to fast during Ramadan. The updated guidelines focus on newer hypoglycemic agents and management during the COVID-19 pandemic. See the paper for more details. 5

Auteur(s)

David C. Slawson, MD

Question clinique

Does use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) increase the likelihood or severity of COVID-19 infection?

L’Essentiel

This large and well-conducted Italian case-control study found no association between the use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) and either infection or severe illness with COVID-19. <a href="https://www.nejm.org/doi/10.1056/NEJMoa2008975">Another study</a> in the same issue of the journal used data from New York City and came to the same conclusions. 3b

Auteur(s)

Mark H. Ebell, MD, MS

Question clinique

What are the effects of convalescent plasma in patients with COVID-19?

L’Essentiel

Convalescent plasma marginally increased the rates of clinical improvement in severely ill patients in China, but these results are compromised by the early termination of the trial. 2b

Auteur(s)

John Hickner, MD, MS

Question clinique

Are patients with cancer treated for COVID-19 at higher risk of mortality than other cancer patients?

L’Essentiel

Patients who are currently being treated for cancer are not at an increased risk of death from COVID-19 compared with other cancer patients. 2b

Auteur(s)

Mark H. Ebell, MD, MS

Question clinique

Can patient-collected swabs accurately detect the presence of SARS-CoV-2? What symptoms and laboratory findings are common in patients with COVID-19?

L’Essentiel

Self-collected swabs are accurate in detecting SARS-CoV-2 in ambulatory settings. Fever, cough, elevated C-reactive protein levels, and ground glass opacities are common in patients with COVID-19 in China. 2c

Auteur(s)

Henry C. Barry, MD, MS

 

 

*Avertissement L’abréviation « POEMs » vient de « Patient-Oriented Evidence that Matters » (données probantes et pertinentes axées sur les patients). Les POEMs sont publiés par John Wiley and Sons, Inc. et distribués par Joule comme service aux membres de l’AMC. Tous les éléments du contenu sont présentés à titre informatif et éducatif seulement et ne remplacent en rien les conseils d’un médecin. Joule se dégage de toute responsabilité civile ou légale découlant de toute erreur ou omission, ou de l’utilisation de tout renseignement contenu aux présentes.